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. 2019 Oct 29;47(21):11430–11440. doi: 10.1093/nar/gkz965

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — A linked secondary structure and sugar pucker equilibrium for the selection of catalytically relevant states. The sugar pucker equilibrium of the branch site adenosine and the secondary structure distributions during the two steps of group II intron catalysis are given. Inactive folds for the forward self-splicing pathway are shown transparent. These states are the active states in the reverse splicing pathway. Our data strongly supports a conformational selection mechanism in group II intron catalysis to guarantee the availability of reaction competent states for either the forward or backward reaction pathway.