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. 2019 Oct 31;47(21):11197–11208. doi: 10.1093/nar/gkz961

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Model for DREAM and RB repression of cell cycle gene expression after p53 activation. P53 activation by DNA damage or inhibition of MDM2 results in increased expression of p21 and inhibition of Cyclin E-CDK2. Decreased CDK2 activity results in restoration of RB and DREAM mediated repression of G1/S gene expression. Under these conditions, DREAM and p107-DREAM are able to bind and repress G1/S and G2/M genes, promoting cell cycle arrest.