Table 2.
Positive rates of the autoantibodies in different patient groups
| Autoimmune antibodies | Cutoff | Control (n = 59) | One sporadic miscarriage (n = 89) | Recurrent pregnancy loss (n = 125) | |||
|---|---|---|---|---|---|---|---|
| Positive rate | Mean ± SD | Positive rate | Mean ± SD | Positive rate | Mean ± SD | ||
| aPT IgG | 18 U/mL | 1.6% (1) | 2.8 ± 3.5 | 3.4% (3) | 5.1 ± 6.9 | 1.6% (2) | 4.5 ± 4.1 |
| aPT IgM | 18 U/mL | 0.0% (0) | 3.8 ± 2.9 | 9.0% (8) | 8.1 ± 7.6 | 10.4% (13) | 9.0 ± 7.9 |
| aAnxV IgG | 18 U/mL | 0.0% (0) | 1.1 ± 1.2 | 2.3% (2) | 4.2 ± 5.9 | 0.8% (1) | 3.1 ± 2.4 |
| aAnxV IgM | 18 U/mL | 1.7% (1) | 1.4 ± 6.7 | 1.1% (1) | 2.4 ± 6.4 | 1.6% (2) | 2.2 ± 4.2 |
| aPS IgG | 18 U/mL | 0.0% (0) | 1.8 ± 1.0 | 2.3% (2) | 5.9 ± 7.3 | 1.6% (2) | 5.1 ± 9.1 |
| aPS IgM | 18 U/mL | 0.0% (0) | 1.2 ± 0.6 | 4.5% (4) | 6.3 ± 11.1 | 2.4% (3) | 4.2 ± 4.6 |
| aPE IgG | 18 U/mL | 0.0% (0) | 5.0 ± 2.0 | 19.1% (17) | 13.1 ± 9.4 | 12.8% (16) | 18.3 ± 55.7 |
| aPE IgM | 18 U/mL | 3.4% (2) | 6.4 ± 4.0 | 23.6% (21) | 12.8 ± 9.8 | 40.0% (50) | 18.6 ± 14.9 |
| aTG IgG | 180 IU/mL | 0.0% (0) | 12.2 ± 16.9 | 5.6% (5) | 39.5 ± 131.3 | 4.8% (6) | 28.2 ± 106.4 |
| aTPO IgG | 60 IU/mL | 5.1% (3) | 11.2 ± 37.1 | 7.9% (7) | 39.9 ± 136.5 | 10.4% (13) | 52.5 ± 213.6 |
| anti‐sperm IgG | S/Co = 1 | 3.4% (2) | 0.2 ± 0.2 | 5.6% (5) | 0.5 ± 0.9 | 5.6% (7) | 0.4 ± 0.9 |
| aEM IgG | S/Co = 1 | 1.7% (1) | 0.3 ± 0.2 | 14.6% (13) | 0.8 ± 0.4 | 13.6% (17) | 0.7 ± 0.5 |
| ANA | 1:80 titer | 0.0% (0) | ND | 7.9% (7) | ND | 15.2% (19) | ND |
The positive rate of each autoimmune antibody tested was calculated as the percentage of the frequency of the positive results (indicated in parenthesis) over the total patient number of each group.
All cutoff values were provided by the manufacturers' package inserts.
Abbreviations: aAnxV, anti‐annexin V; aEM, anti‐endometrium; ANA, anti‐nuclear antibodies; aPE, anti‐phosphotidylethanolamine; aPS, anti‐phosphotidylserine; aPT, anti‐prothrombin; aTG, anti‐thyroglobulin; aTPO, anti‐thyroid peroxidase; ND, not determined; S/CO, signal‐to‐cutoff ratio.