Table 2.

MVPs associated with incident T2DM at P < 1.0E-07 in EPIC-Norfolk (N = 1,264)

CpG identifier	Chr	Position	OR	95% CI	P	FDR	Gene name	Gene position
cg19693031	1	144152909	0.52	0.46–0.6	2.7E-21	1.3E-15	TXNIP	3′ UTR
cg06500161	21	42529656	1.65	1.45–1.89	6.4E-14	1.5E-08	ABCG1	Body
cg14476101	1	120057515	0.67	0.59–0.76	2.8E-10	3.9E-05	PHGDH	Body
cg14020176	17	70276580	1.63	1.4–1.9	3.3E-10	3.9E-05	SLC9A3R1	3′ UTR
cg11024682	17	17670819	1.56	1.35–1.79	6.0E-10	5.7E-05	SREBF1	Body
cg06397161	22	38090005	1.51	1.32–1.73	4.5E-09	3.3E-04	SYNGR1	Body; TSS200
cg00574958	11	68364198	0.69	0.61–0.78	5.2E-09	3.3E-04	CPT1A	5′ UTR
cg06235429	11	67129690	1.49	1.3–1.7	5.5E-09	3.3E-04	NDUFV1	TSS1500
cg05778424	17	52524507	1.69	1.42–2.02	7.4E-09	3.9E-04	AKAP1	5′ UTR
cg11376147	11	57017774	0.68	0.59–0.77	1.3E-08	6.0E-04	SLC43A1	Body
cg04816311	7	1033176	1.51	1.31–1.75	1.7E-08	7.2E-04	C7orf50	Body
cg02711608	19	51979804	0.69	0.6–0.79	4.5E-08	1.5E-03	SLC1A5	1st exon; 5′ UTR
cg08309687	21	34242466	0.68	0.6–0.78	4.5E-08	1.5E-03
cg13514042	7	1158728	1.42	1.25–1.61	4.5E-08	1.5E-03
cg08994060	10	6254032	0.65	0.55–0.76	5.2E-08	1.6E-03	PFKFB3	Body
cg01676795	7	75424284	1.56	1.33–1.84	6.5E-08	1.8E-03	POR	Body
cg25130381	1	27313308	1.49	1.29–1.73	6.7E-08	1.8E-03	SLC9A1	Body
cg11183227	15	89256411	1.49	1.29–1.72	7.0E-08	1.8E-03	MAN2A2	Body

Position: by HapMap build 37. OR: odds ratio per 1 SD in methylation intensity. Genes: gene names in which the CpG falls from 1,500 bp upstream of the transcriptional start site to the end of the 3′ UTR as in Illumina’s Infinium Human Methylation 450K BeadChip manifest file. Chr, chromosome; FDR, false discovery rate.