Figure 1.

Temporal pattern of risk of stroke/transient ischaemic attack after an episode of worsening chronic heart failure with reduced ejection in the placebo arm of COMMANDER HF. The total duration of time was calculated by adding the time from worsening heart failure episode to randomization to the time from randomization to stroke/transient ischaemic attack. The incremental incidence rate (red bars)) and its 95% confidence intervals (grey lines) for each time segment were derived using the bootstrap method (10 000 resamples). Kaplan–Meier cumulative risk estimates over the first 12 months after an episode of worsening heart failure are displayed in blue.