Figure 4.

Investigation of other R882 mutants. (A) Catalytic activities of R882 mutations determined with a 30mer substrate. The figure shows averages of at least 3 independent experiments. Error bars display the standard deviation. R882H data were taken from Emperle et al. (19). (B) Correlation of NNCGNN methylation profiles determined by deep enzymology using the data obtained with unmethylated substrates. For comparison, all data sets were reduced to equal read counts of 38 000. (C) Weblogos of the 20 most preferred and disfavored flanks by the R882 mutants based on the NNCGNN profiles.