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. 2019 Oct 17;47(21):11355–11367. doi: 10.1093/nar/gkz911

Table 1.

List of potential R882H AML target genes. Gene part refers to the region of hypermethylation (P – promoter, I – Intron, EX – Exon, D – Distance) as defined in (31). CpGs: number of hypermethylated CpGs. Expression: ln2 ratio of expression level in R882H and non-R882H AML. Comment: Oncogene and TSG (Tumor suppressor gene) as listed in COSMIC Cancer gene census (52) or the indicated references. AML connection is based on Harmonizome AML gene set (53)

Category Gene Gene symbol Gene part CpGs Expression Comment
Hypermet. promoter NM_014629 ARHGEF10 P 1 –0.85 TSG
NM_001135733 TP53INP1 P 1 –0.91 Negative clinical marker (50)
NM_016831 PER3 P 1 –0.55 (49)
Hypermet. gene body NM_022114 PRDM16 I 4 1.04 Ongogene, AML connection
NM_000378 WT1 I 4 0.94 Oncogene, TSG, AML connection
NM_024083 ASPSCR1 I 3 0.57
NM_000368 TSC1 I 1 0.64 TSG
NM_032173 ZNRF3 I 1 –0.58 TSG
NM_000179 MSH6 I 1 –1.16 TSG
NM_181523 PIK3R1 I 1 –1.49 TSG
NM_001136239 PRDM6 I 3 –0.52 TSG (54)
NM_001535 PRMT2 EX 1 0.53 Oncogene (55)
Hypermet. close to gene NM_007084 SOX21 D 1 –0.54 TSG
NM_004496 FOXA1 D 3 –0.52 Oncogene, TSG
NM_001013736 FAM47C D 1 –0.35
NM_015274 MAN2B2 D 1 0.58 Listed in AML gene set
NM_002609 PDGFRB D 1 0.66 Oncogene