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. 2019 Nov 14;10:1314. doi: 10.3389/fphar.2019.01314

Figure 5.

Figure 5

Proposal of changes in intrarenal renin–angiotensin system (iRAS) components during the inflammatory stage of UUO. Obstructive uropathy at 7 days (recognized as “the pro-inflammatory phase”) induces tubular remodeling and iRAS activation in the cortex, as reflected by the renin increase in dilated tubules. This activation may be counteracted by the iRAS components in the medulla, particularly by PRR.