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. 2019 Nov 14;10:1332. doi: 10.3389/fphar.2019.01332

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Copyright © 2019 Yang, Lu, Huo, Chen, Cao, Xie, Zhou, Liu, Liu and Yu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LGS suppresses the release of IL-6 in LPS-induced RAW264.7 cells. (A) LGS (50−200 μg/ml) has no obvious cytotoxicity in RAW264.7 macrophage cells. The cell cytotoxicity of LGS was confirmed by MTT assay. (B) LGS inhibits the production of IL-6 in LPS-induced RAW264.7 cells. Macrophages were cultivated with LGS (200 μg/ml) or dexamethasone (DEX, as a positive control) (100 μM) in the presence of LPS (1 μg/ml) for 24 h. The level of IL-6 in supernatants was analyzed by ELISA. Data are represented as the mean ± SEM of three independent experiments. ^### P < 0.001 versus control, **P < 0.01, ***P < 0.001 versus LPS treatment by one-way ANOVA with Tukey’s test.