Table 2.

Plasma concentration of TRP and its metabolites in FAP, high-risk adenoma and colon cancer patients.

	FAP (n = 25)		Adenomaa (n = 12)		Colon cancera (n = 41)
	Median	Q1; Q3	Median	Q1; Q3	Median	Q1; Q3	P values
TRP µg/mL	8.23	7.19; 10.18	7.34	5.44; 9.52	5.77	4.71; 7.17	<.01 b
KYN µg/mL	0.30	0.25; 0.34	0.35	0.28; 0.43	0.32	0.24; 0.40
5HTP µg/mL	0.03	0.03; 0.04	0.04	0.04; 0.06	0.05	0.04; 0.08	<.05c; <.001b
5-HT µg/mL	0.01	0.01; 0.03	0.01	0.009; 0.01	0.01	0.01; 0.02

Abbreviations: FAP, familial adenomatous polyposis, 5HTP, 5-hydroxy-tryptophan; KYN, kynurenine; TRP, tryptophan; 5-HT, serotonin

^aHigh-grade adenoma (ADE) and colorectal cancer (CRC) data retrieved from the reference study.

^bFAP vs ADE p value after Dunn’s Multiple Comparison Test

^cFAP vs CRC p value after Dunn’s Multiple Comparison Test.