Table 3.
Meta-Analysis of the Association Between CAR and Clinicopathological Features of CRC.
| Characteristics | No. of Studies | No. of Patients | OR (95% CI) | P | Heterogeneity | |
|---|---|---|---|---|---|---|
| I 2 (%) | Ph | |||||
| Age (>median vs <median) | 3 | 830 | 1.73 (0.84-3.56) | .14 | 67 | 0.05 |
| Gender (male vs female) | 4 | 966 | 1.71 (1.30-2.24) | <.001 | 0 | 0.57 |
| Tumor location (left vs right) | 3 | 339 | 1.34 (0.33-5.42) | .68 | 83 | 0.003 |
| Tumor diameter (≥50 mm vs <50 mm) | 1 | 627 | 3.69 (2.61-5.21) | <.001 | - | - |
| Differentiation (low vs moderate/high) | 3 | 1468 | 1.51 (1.00-2.27) | .05 | 0 | 0.90 |
| TNM stage (III-IV vs I-II) | 1 | 163 | 3.45 (1.76-6.77) | <.001 | - | - |
| CEA (>8.7 ng/mL vs <8.7 ng/mL) | 1 | 627 | 3.70 (2.51-5.47) | <.001 | - | - |
| CA19-9 (>9.5 ng/mL vs <9.5 ng/mL) | 1 | 627 | 1.89 (1.37-2.60) | <.001 | - | - |
| Lymphatic invasion (yes vs no) | 3 | 1468 | 1.29 (1.02-1.64) | .03 | 43 | 0.17 |
| Venous invasion (yes vs no) | 3 | 1468 | 1.37 (1.04-1.81) | .03 | 0 | 0.43 |
Abbreviations: CAR, C-reactive protein to albumin ratio; CA19-9, carbohydrate antigen 19-9; CRC, colorectal cancer; CEA, carcinoembryonic antigen; CI, confidence interval; OR, odds ratio; TNM, tumor node metastasis.