Table 3.

Genes and variants identified from the gene-score analysis step for cancer BRONJ cases

No.	Genes					Variants
	Hugo	Gene name	Gene score		p value	Chr	Pos	Ref/Alt	SIFT/CADD	AF	p value
			Case	Control						Case/control
1	ARID2	AT-rich interaction domain 2	0.41 ± 0.49	0.83 ± 0.83	< 0.001	chr12	46,246,206	G/T	0.02/15.55	0.23/0.07	0.015
2	CDC27	Cell division cycle 27	0.69 ± 0.48	0.97 ± 0.18	< 0.001	chr17	45,214,654	C/T	0/20.6	0.15/0.01	0.003
3	HEBP1	Heme-binding protein 1	0.77 ± 0.44	0.98 ± 0.15	0.001	chr12	13,128,263	C/G	0/20.1	0.12/0.01	0.015
4	LTBP1	Latent transforming growth factor beta-binding protein 1	0.52 ± 0.43	0.81 ± 0.24	0.018	chr2	33,505,139	C/A	0/32	0.15/0.03	0.016
5	PLVAP	Plasmalemma vesicle-associated protein	0.81 ± 0.37	0.96 ± 0.16	0.029	chr19	17,476,328	G/A	0.01/6.50	0.08/0.01	0.043
6	TNRC18	Trinucleotide repeat containing 18	0.73 ± 0.27	0.89 ± 0.22	0.003	chr7	5,427,467	G/A	0.01/16.78	0.08/0.01	0.043

AF allele frequency