Table 1.
Baseline characteristics of non-ARDS and ARDS participants
| Non-ARDS (n = 822) | ARDS (n = 310) | p value | |
|---|---|---|---|
| Age (years) | 60.3 (16.6) | 59.1 (15.9) | 0.23 |
| Male | 440 (53.5) | 170 (54.8) | 0.69 |
| African-American | 209 (25.4) | 61 (19.7) | 0.04 |
| Medical ICU | 375 (45.6) | 164 (52.9) | < 0.001 |
| Initial admitting diagnosisa | |||
| Respiratory | 416 (50.6) | 230 (74.2) | < 0.001 |
| Neurological | 251 (30.5) | 48 (15.5) | < 0.001 |
| Cardiovascular | 226 (27.5) | 84 (27.1) | 0.89 |
| Infectious | 221 (26.9) | 138 (44.5) | < 0.001 |
| Gastrointestinal | 122 (14.8) | 44 (14.2) | 0.78 |
| Trauma | 61 (7.4) | 9 (2.9) | 0.005 |
| Endocrine | 38 (4.6) | 12 (3.9) | 0.58 |
| Other | 134 (16.3) | 37 (11.9) | 0.067 |
| Sepsis | 261 (31.8) | 190 (61.7) | < 0.001 |
| Pneumonia | 250 (30.4) | 148 (47.7) | < 0.001 |
| APACHE II | 20.2 (7.4) | 22.1 (7.7) | < 0.001 |
| SOFA | 6 (4–9) | 8 (5–11) | < 0.001 |
| PaO2/FiO2 | 255.6 (150.7) | 174.8 (102.3) | < 0.001 |
| Compliance respiratory system | 39.6 (28.2) | 35.1 (35.6) | 0.04 |
| Plateau pressure | 20.6 (6.5) | 23.9 (7.1) | < 0.001 |
| Driving pressure | 14.3 (6.0) | 16.0 (6.4) | < 0.001 |
| PEEP | 5 (5–8) | 7 (5–10) | < 0.001 |
| Tidal volume (mL/kg PBW) | 7.2 (1.21) | 6.78 (1.19) | < 0.001 |
| Hospital LOS | 18 (10–30) | 19 (10–33) | 0.43 |
| ICU LOS | 10 (5–17) | 11 (6–18) | 0.04 |
| Ventilator days | 7 (3–14) | 9 (5–15) | 0.01 |
| Mortality | 224 (27.3) | 120 (38.7) | < 0.001 |
Abbreviations: ARDS acute respiratory distress syndrome, APACHE Acute Physiologic and Chronic Health Evaluation, SOFA Sequential Organ Failure Assessment, ICU intensive care unit, PEEP positive end-expiratory pressure, PBW predicted body weight, LOS length of stay
Data presented as mean (SD), median (IQR), or n (%)
aMay have more than one admitting diagnosis. Does not sum to 100%