Table 2.
Odds of hospital mortality from multivariable logistic regression
| Non-ARDS | ARDS | |||||
|---|---|---|---|---|---|---|
| ORa | 95% CI | p value | ORa | 95% CI | p value | |
| Driving pressure (per 7 cm H2O)b | 1.36 | 1.14–1.62 | < 0.001 | 1.63 | 1.22–2.16 | < 0.001 |
| Plateau pressure (per 8 cm H2O)b | 1.42 | 1.17–1.73 | < 0.001 | 1.74 | 1.26–2.41 | < 0.001 |
| Age (per 5 years) | 1.05 | 0.98–1.11 | 0.125 | 1.09 | 0.99–1.20 | 0.07 |
| PEEP (per 1 cm H2O) | 1.05 | 0.98–1.11 | 0.16 | 1.12 | 1.07–1.17 | < 0.001 |
| APACHE II (per 1 point) | 1.08 | 1.04–1.11 | < 0.001 | 1.08 | 1.04–1.12 | < 0.001 |
| Vasopressor use | 1.52 | 1.06–2.16 | 0.02 | 1.02 | 0.56–1.85 | 0.94 |
| Sepsis | 1.12 | 0.77–1.62 | 0.56 | 1.03 | 0.62–1.69 | 0.90 |
Abbreviations: ARDS acute respiratory distress syndrome, APACHE Acute Physiologic and Chronic Health Evaluation, PEEP positive end-expiratory pressure, OR odds ratio
Estimates for covariates are derived from the driving pressure model. The plateau pressure model included the same covariates as the driving pressure model
aOdds ratio adjusted for age, sex, PEEP, APACHE II, vasopressor use, sepsis, hospital volume, and ICU category
bOdds ratios for driving pressure and plateau pressure are scaled to IQRs