Table 3.

Univariate and multivariate analyses for OS in cohorts A and B combined

	Cohort A				Cohort B
Factors	Univariate analysis HR (95% C.I.)	p	Multivariate analysis HR (95% C.I.)	p	Univariate analysis HR (95% C.I.)	p	Multivariate analysis HR (95% C.I.)	p
Age (≥ 65 vs ≤ 65)	0.9 (0.80–1.04)	0.18	–	–	1.13 (0.86–1.47)	0.38	–	–
Gender
(male vs female)	1.03 (0.89–1.18)	0.73	–	–	1.20 (0.87–1.67)	0.27	–	–
ECOG PS
1 vs 0	1.59 (1.37–1.83)	< 0.0001	1.45 (1.24–1.69)	< 0.0001	1.59 (1.20–2.11)	0.001	1.51 (1.14–2.00)	0.04
2 vs 0	3.47 (2.71–4.45)	< 0.0001	3.09 (2.38–4.02)	< 0.0001	2.53 (1.54–4.17)	< 0.0001	2.46 (1.49–4.05)	< 0.0001
Smoking habits
Current/former vs never	0.85 (0.72–1.00)	0.05	–	–	1.27 (0.79–2.07)	0.32	–	–
Brain mets (yes vs no)	1.24 (1.06–1.43)	0.006	–	–	1.07 (0.70–1.63)	0.75	–	–
Liver mets (yes vs no)	1.84 (1.58–2.15)	< 0.0001	1.64 (1.39–1.93)	< 0.0001	1.58 (1.16–2.15)	0.004	1.43 (1.01–1.95)	0.03
Bone mets (yes vs no)	1.67 (1.46–1.91)	< 0.0001	1.50 (1.30–1.73)	< 0.0001	1.90 (1.47–2.47)	< 0.0001	1.78 (1.37–2.31)	< 0.0001
Previous CT Lines
2 vs 1	0.87 (0.73–1.03)	0.10	–	–	0.91 (0.61–1.22)	0.54	–	–
> 2 vs 1	1.03 (0.88–1.21	0.67			0.73 (0.53–1.02)	0.06