Table 2.
Top gene sets associated with arsenic exposure
| Gene set | NES |
|---|---|
| A. Female | |
| Upregulated | |
| KEGG OXIDATIVE PHOSPHORYLATION | 3.86 |
| REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | 3.76 |
| REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION | 3.75 |
| REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | 3.71 |
| REACTOME MEMBRANE TRAFFICKING | 3.70 |
| Downregulated | |
| NABA CORE MATRISOME | −4.59 |
| REACTOME PEPTIDE CHAIN ELONGATION | −4.57 |
| KEGG RIBOSOME | −4.40 |
| REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | −4.12 |
| REACTOME SIGNALING BY GPCR | −3.87 |
| B. Male | |
| Upregulated | |
| REACTOME UNFOLDED PROTEIN RESPONSE | 2.17 |
| REACTOME INSULIN RECEPTOR RECYCLING | 2.10 |
| REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | 2.04 |
| REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | 2.01 |
| REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | 1.99 |
| Downregulated | |
| NABA CORE MATRISOME | −2.78 |
| NABA ECM GLYCOPROTEINS | −2.54 |
| PID INTEGRIN1 PATHWAY | − 2.37 |
| KEGG VASCULAR SMOOTH MUSCLE CONTRACTION | −2.36 |
| NABA COLLAGENS | −2.36 |
NES normalized enrichment score