Table 4.

Multivariable analysis of factors associated with in-hospital mortality during admission for infective endocarditis according to T2DM status

	T2DM	No T2DM	Total
	OR (95% CI)	OR (95% CI)	OR (95% CI)
Time period	0.8 (0.8–0.9)	0.8 (0.8–0.9)	0.8 (0.8–0.9)
Female sex	1.3 (1.1–1.6)	NS	1.2 (1.0–1.3)
Agea	1.8 (1.6–2.0)	1.8 (1.6–2.0)	1.8 (1.7–2.0)
Charlson Comorbidity Index	1.6 (1.5–1.8)	1.6 (1.5–1.8)	1.7 (1.5–1.8)
Acute renal disease	2.0 (1.6–2.5)	1.9 (1.5–2.4)	2.0 (1.7–2.3)
Ischemic heart disease	1.3 (1.0–1.6)	NS	NS
COPD	0.7 (0.5–0.9)	0.7 (0.5–0.9)	0.7 (0.6–0.8)
Shock	8.6 (6.1–12.1)	7.1 (5.0–10.1)	7.4 (5.8–9.5)
Dialysis	2.5 (1.8–3.5)	1.8 (1.3–2.6)	2.1 (1.7–2.7)
Pacemaker implantation	NS	0.4 (0.2–0.8)	0.5 (0.3–0.9)
Mechanical ventilation	3.3 (2.5–4.4)	3.7 (2.8–4.8)	3.4 (2.8–4.1)
Staphylococcus aureus	NS	NS	1.2 (1.0–1.5)
Streptococci	0.6 (0.5–0.8)	0.4 (0.3–0.6)	0.5 (0.4–0.6)
Enterococci	NS	0.6 (0.5–0.9)	0.8 (0.6–0.9)
Streptococcus pneumoniae	NS	NS	0.2 (0.0–1.0)
T2DM	NA	NA	1.1 (0.9–1.2)

Only those variables that showed a significant association after multivariable adjustment are showed

T2DM type 2 diabetes mellitus, COPD chronic obstructive pulmonary disease, OR odds ratio obtained using logistic regression models, 95% CI 95% confidence intervals, NS not significant, NA Not applicable

^aAge was introduced as a continuous variable with three categories. Additional file 6: Table S5 shows which study variables were associated with the IHM in the bivariate analysis among those with and without T2DM. All those variables significantly associated with IHM were included in the multivariable model. The variables not always significant and included in the multivariable models because they were considered relevant in other investigations were: prosthetic valve carriers, previous mitral valve disease, previous aortic valve disease, COPD, Gram-negative bacilli, Candidiasis/aspergillosis, readmissions, heart valve surgery, Coagulase-negative staphylococci and Streptococcus pneumoniae