Table 1.

Study schedule of enrollment, interventions, and assessments

	Study period
	Enrollment	Allocation	Post allocation
Time point	−4 weeks	0	Week 0–6	Week 10	Weeks 11–34	Within 2 years	3–5 years	5–10 years
Enrollment:
Eligibility screen	X
Informed consent	X
Randomization	X
Allocation		X
Interventions:
RT			X
Concurrent TMZ			X
Adjuvant TMZ				X	X
Assessments:
Physical examination		X				Every 3 months	Every 6 months	Annually
KPS		X		X		Every 3 months	Every 6 months	Annually
CBC		X	Weekly	X	Weekly
Serum biochemistry		X	Weekly	X	Weekly
Postoperative head MRI	X			X		Every 3 months	Every 6 months	Annually
Cognitive function	X			X		Every 3 months	Every 6 months	Annually
Adverse events			X	X	X	Every 3 months	Every 6 months	Annually

Abbreviations: RT radiation therapy, TMZ temozolomide, KPS Karnofsky performance score, CBC complete blood count, MRI magnetic resonance imaging