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. 2019 Nov 21;18:166. doi: 10.1186/s12943-019-1098-8

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© The Author(s). 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Increased expression of circERBB2 indicates worse prognosis of GBC patients. a CircERBB2 expression level was determined by FISH. b Survival probability was calculated with Kaplan-Meier survival analysis. Increased expression of circERBB2 indicated worse prognosis of GBC patients (n = 149). c circERBB2 showed significantly positive correlation with PA2G4 in GBC tissues, but not in para-cancer tissues (n = 28). d Proposed model of the circERBB2-PA2G4-TIFIA complex in upregulating rDNA transcription and GBC progression