Table 2.

Mechanisms of action reported for 25 lncRNAs

Name	Sp.	LncRNA action	Ref.
APOA1-AS	h	Histone mark modification via LSD1 et SUZ12 (PRC2)	[41]
APOA4-AS	m	Complex lnc:HuR et APOA4 mRNA	[42]
Blnc1a	m	Complex lnc:hnRNPU / Complex lnc:EDF1, lnc:LXRa	[95]
CASIMO1a	h	Small protein CASIMO1 interacts with SQLE protein	[45]
H19	m	Complex lnc:PTBP1 which targets SREBP1c mRNA and protein stability and transcriptional activity	[50]
LeXis	m	Complex lnc:RALY (hnRNP) which targets SREBP2, HMGCR, CYP51A1, FDPS promoters	[55]
LINC01138	h	Comple lnc:PRMT5 which targets SREBP1 in order to regulate its arginine methylation and to stabilize SREBP1 mRNA	[56]
linc-ADALa	h	Complex lnc:IGF2BP2 and hnRNPU	[57]
LINK-Aa	h	Complex lnc:PIP3 increases interaction with Akt	[59]
lnc-HC	r	Complex lnc:hnRNPA2B1 which targets CYP7A1/ABCA1 mRNAs	[65]
Lnc-leptina	m	Loop between LEP and its enhancer (near lnc:leptin locus)	[68]
lncLGRa	m	Complex lnc:hnRNPL which targets GCK promoter	[96]
lncLSTR	m	Complex lnc:TDP-43 which targets CYP8B1 promoter	[69]
lncSHGLa	m	Complex lnc:hnRNPA1 which targets CALM mRNA to increase its translation	[71]
LNMICCa	h	Complex lnc:NPM1 which targets FABP5 promoter	[72]
MALAT1	h	Complex lnc:SREBP1c which stabilizes nuclear SREBP1c protein	[75]
MEG3	h,m	Complex lnc:PTBP1 which targets SHP mRNA for its decay	[76]
MeXis	m	Complex lnc:DDX17 which targets ABCA1 promoter	[37]
NEAT1	h	Complex lnc:NONO:CD36 mRNA	[79]
	h	ceRNA (miR-124-3p which targets ATGL)	[80]
PVT1a	h	ceRNA (miR-195 which targets FASN)	[83]
RALGAPA1-AS1a	h,m	Stop maturation of pri-miRNA (pri-miR-195/pri-miR-4668)	[93]
S1PR1-DTa	h	Complex lnc:ZNF354C which inhibits its repressive activity	[60]
SNHG14	m	ceRNA (miR-145-5p which targets PLA2G4A)	[87]
SNHG16a	h	ceRNA (multiple miRNA which target SCD) & Complex lnc:HuR	[88]
SPRY4-IT1a	h	Complex lnc:Lipin2	[89]

^agenes not described in previous reviews