Recent updates on daidzein against oxidative stress and cancer



Dear Editor,

Daidzein (7-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one) is a naturally occurring compound commonly found in soybeans and some other legumes. Daidzein is an isoflavone by nature and isolated from Pueraria Mirifica, having category of biologically active secondary metabolites commonly produced in the soybean growth and belong to the group of flavonoids. A number of pharmacological activities have been accounted for daidzein, which includes anti-carcinogenesis, anti-fibrotic, anti-diabetic, cholesterol-lowering and cardiovascular activity. Daidzein pretreatment was found to diminish the seriousness of mucosal damage in a portion subordinate way. Some other therapeutic uses of daidzein are weight reduction, decreasing bowels moment, and inflammation associated with histopathological deformities (Amaral et al., 2017[1]). Their structure and function are alike to human estrogen, which can play a massive role in the prevention of osteoporosis, cancer, and postmenopausal syndromes. Uses of daidzein in anticancer activity against ovarian cancer are still limited (Meng et al., 2017[14]). Epidemiological data suggest that increased utilization of soybean in food results in decreased cancer risk. Soybean food is highly recommended in cancer prevention because it has a number of anticarcinogens (Yu et al., 2017[23]). The potent antioxidant activity of daidzein reported in various in vitro and in vivo studies was conclusively shown in this literature (Table 1(Tab. 1); References in Table 1: Amaral et al., 2017[1]; Atiq et al., 2019[2]; Budryn et al., 2018[3]; Chan et al., 2018[4]; Davis et al., 2001[5]; Eskra et al., 2019[6]; Foti et al., 2005[7]; Gundogdu et al., 2018[8]; Hua et al., 2018[9]; Huang et al., 2019[10]; Karale and Kamath, 2017[11]; Liang et al., 2018[12]; Medeiros et al., 2016[13]; Meng et al., 2017[14]; Murata et al., 2004[15]; Park et al., 2016[16]; Poschner et al., 2017[17]; Rigalli et al., 2019[18]; Rohrdanz et al., 2002[19]; Sivoňová et al., 2019[20]; Uifalean et al., 2018[21]; Wei et al., 2019[22]; Zheng et al., 2017[25]; Zheng et al., 2018[24]; Zhu et al., 2018[26]).

Table 1. Recent updates on daidzein against oxidative stress and cancer.

Conflict of interest

The authors declare no conflict of interest.