Figure 2.
Direct comparison between patients with major depressive disorder (MDD) and healthy controls in serotonin transporter (SERT) associations between the midbrain dorsal raphe nucleus (DRN) and projection areas. (a) As shown in the maximum intensity projection (SPM8 glass brain), voxel‐wise ANCOVA resulted in group differences only within the ventral striatum of both hemispheres (incl. nucleus accumbens, P < 0.001, k > 20 voxels). Coronal plane is at y = 17 mm MNI‐space, left is right. (b,c) Scatter plots are extracted for the entire cluster which is marked by the red circle. Healthy subjects (b, R 2 = 0.72) but not MDD patients (c, R 2 = 0.11) show a strong SERT association between the DRN and the ventral striatum. See Table 2 for details. [Color figure can be viewed in the online issue, which is available at http://wileyonlinelibrary.com.]