Table 2.
Results from the between‐group comparisons of hippocampal dentate gyrus vertex analysis
| Right dentate gyrus | Left dentate gyrus | |||||
|---|---|---|---|---|---|---|
| No. vertices | Mean (SD) | Percentage change | No. vertices | Mean (SD) | Percentage change | |
| RRMS > HC | 56 | 2.66 (0.76) > 2.14 (0.78) | 24.5 | 148 | 2.40 (0.71) > 1.83 (0.65) | 31.1 |
| SPMS > HC | 18 | 2.47 (0.83) > 1.99 (0.69) | 24.2 | 164 | 2.67 (0.71) > 2.19 (0.70) | 21.5 |
| BMS > HC | – | – | 6 | 2.55 (0.65) > 2.15 (0.63) | 18.8 | |
| RRMS > SPMS | 18 | 2.66 (0.82) > 2.21 (0.69) | 19.9 | 63 | 2.75 (0.62) > 2.37 (0.67) | 16.1 |
| SPMS > RRMS | – | – | 38 | 3.15 (0.73) > 2.56 (0.70) | 23.4 | |
| RRMS > BMS | 58 | 2.84 (0.83) > 2.27 (0.84) | 25.0 | 184 | 3.01 (0.74) > 2.48 (0.70) | 21.5 |
| BMS > RRMS | – | – | 8 | 3.39 (0.85) > 2.79 (1.02) | 21.3 | |
| SPMS > BMS | 123 | 3.84 (0.89) > 3.21 (1.09) | 19.7 | 56 | 3.33 (0.80) > 2.82 (0.74) | 18.0 |
| BMS > SPMS | – | – | – | – | ||
The number of surface vertices out from the 900 of the dentate gyrus, showing a statistically significant difference in radial distance at between‐group comparisons (P < 0.05), radial distance means, SDs (in mm), and percentage of changes (i.e., relative difference between the means of the two groups being compared) for the significant vertices are provided.
HC = healthy controls; MS = multiple sclerosis; RR = relapsing‐remitting; SP = secondary progressive; BMS = benign MS; SD = standard deviation.