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. 2014 Feb 7;35(8):4140–4154. doi: 10.1002/hbm.22466

Figure 5.

Figure 5

Volume of interest (VOI) analyses of the effect of oddball stimulus relevance on evoked LC BOLD responses with spatial smoothing. A, Parameter estimates for target versus standard stimuli at each level of the informed basis set (C: canonical HRF; T: temporal derivative; D: dispersion derivative), where the VOI was defined by the overlap between the LC atlas and the dorsal pontine cluster identified during the task run (“LC/pupil overlap”). Error bars indicate S.E.M. B, Estimated BOLD responses for the LC/pupil overlap VOI, time‐locked to stimulus onset. Shaded area represents S.E.M., black lines indicate latencies at which stimulus‐type effect was statistically significant (P < 0.05, uncorrected). C, Between‐subjects correlation of response time (RT) with peak target‐evoked BOLD response amplitude in the LC/Pupil Overlap VOI. D–F, Parameter estimates, estimated BOLD responses and between‐subjects correlation for a control VOI defined by all remaining voxels in the LC atlas. Format same as A–C, respectively. G–I, Parameter estimates, estimated BOLD responses and between‐subjects correlation for a second control VOI defined by an LC‐adjacent region of the pontine crossing white matter tract. Format same as A–C, respectively. **P < 0.01; n.s.P > 0.2.