Table 3.
Frequency bins of significant correlation between partial coherence (pC) coefficients and DCM estimates of endogenous connections (eC)
| Connectivity | Fb [Hz] | eC | pC | Beta | P |
|---|---|---|---|---|---|
| Top‐down | |||||
| eC_rMFG → rRCZa | fb3 (0.08–0.13) | HC: .02 ± .10 | HC: .55 ± .09 | HC: .62, P < 0.05 | P < 0.05a |
| pAD: .01 ± .07 | pAD: .61 ± .09 | pAD: ‐.08, n. s. | |||
| mI_rMFG → rRCZa | fb3 (0.08–0.13) | HC: ‐.01 ± .20 | HC: .61 ± .09 | HC: ‐.63, P < 0.05 | P < 0.05a |
| pAD: .06 ± .17 | pAD: .54 ± .09 | pAD: .03, n. s. | |||
| eC_rMFG → lSPG | fb3 (0.08–0.13) | HC: .06 ± .14 | HC: .62 ± .10 | HC: ‐.53, P < 0.05 | P < 0.05a |
| pAD: .04 ± .12 | pAD: .58 ± .12 | pAD: .16, n. s. | |||
| eC_rMFG → rSPG | fb4 (0.13–0.15) | HC: .05 ± .23 | HC: .14± .09 | HC: .53, p<.05 | n. s. |
| pAD: .03 ± .19 | pAD: .13 ± .06 | pAD: .33, n. s. | |||
| mI_rMFG → lSPG | No significant correlation in any frequency bin | ||||
| mI_rMFG → rSPG | No significant correlation in any frequency bin | ||||
| Bottom‐up | |||||
| eC_rSPG → rMFG | fb1 (< .03) | HC: .13 ± .15 | HC: .17 ± .10 | HC: .59, P < 0.05, | P < 0.05a |
| pAD: .14 ± .11 | pAD: .23 ± .19 | pAD: ‐.27, n. s. | |||
| eC_lSPG → rSPG | fb1 (< .03) | HC: .06 ± .14 | HC: .13 ± .09 | HC: ‐.62, P = 0.01 | P < 0.05a |
| pAD: .06 ± .19 | pAD: .11 ± .07 | pAD: .25, n. s. | |||
| eC_rSPG → lSPG | no significant correlation in any frequency bin | ||||
| eC_lSPG → rMFG | no significant correlation in any frequency bin | ||||
a
P < 0.05, FDR‐corrected for 40 tests; rMFG, right middle frontal gyrus; lSPG, left superior parietal gyrus; rSPG, right superior parietal gyrus; rRCZa, right rostral cingulate zone, part anterior; HC, healthy controls, pAD, prodromal Alzheimer's Disease.