Figure 4.

BDNF val66met by age interaction effect on [¹¹C]SB20715 binding. Within a post hoc analysis, we observed evidence that BDNF val66met moderated the age effect on [¹¹C]SB207145 binding. This effect is visualized here for neocortex (interaction effect: 0.0049 [0.0024, 0.0073], P = 1.1 × 10⁻⁴). Black and gray dots represent val/val individuals and met‐carriers, respectively. Lines and shading represent genotype slope estimates and 95% confidence intervals, respectively. Data are plotted as log‐transformed neocortex [¹¹C]SB207145 binding values, adjusted for sex, weight‐adjusted injected mass, scanner, BMI and 5‐HTTLPR genotype. Notably, our data suggest that met‐carriers show higher binding through adulthood compared to val/val individuals.