Table 1.
Haplotypea | Major haplotype monozygotes (N = 92) | Heterozygote (N = 181) | Minor haplotype monozygotes (N = 86) | P‐value |
---|---|---|---|---|
Male/Female | 52/40 | 85/96 | 48/38 | 0.216b |
Age | 19.39 ± 0.11 | 19.36 ± 0.08 | 19.49 ± 0.12 | 0.680c |
Education year | 12.28 ± 0.08 | 12.34 ± 0.06 | 12.38 ± 0.09 | 0.702c |
Working memoryd | 0.021e | |||
2‐back accuracy | 0.88 ± 0.07 | 0.90 ± 0.06 | 0.90 ± 0.06 | |
3‐back accuracy | 0.81 ± 0.07 | 0.82 ± 0.07 | 0.84 ± 0.06 |
The haplotype was constructed from six SNPs: rs41420549|rs2981277|rs7013249|rs12681129|rs2930040|rs595255, major haplotype monozygotes = TATTTG/TATTTG, heterozygotes = TATTTG/AGCAAA, and minor haplotype homozygotes AGCAAA/AGCAAA
P value (Pearson_Chi‐square test).
p value (ANOVA).
As described in the Methods section, only 350 subjects (89 major haplotype monozygotes, 177 heterozygotes, and 84 minor haplotype homozygotes) were included in the gene‐working memory analysis.
P value for main effects of RAB2A genotype (repeated measures ANCOVA).