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. 2015 May 22;36(8):3137–3153. doi: 10.1002/hbm.22833

Figure 3.

Figure 3

Neural correlates of psilocybin‐induced ego‐dissolution. (A) Ego‐dissolution correlates with decreased diversity of the anterior parahippocampal (aPHC) connections under psilocybin; (B) Lower diversity of the Left Dorsolateral Prefrontal (regions 141 and 151 in Craddock's atlas) and superior parietal (region 156) regions at baseline predicted ego‐disintegration phenomena under the drug. (C) Decreased integrity of the salience network correlates with ego‐dissolution: scatter plots (LEFT: after the psilocybin administration, RIGHT: difference between baseline and psilocybin‐induced states); results were significant at P < 0.05 (FDR‐corrected); brain template is color‐coded according to the baseline community structure (see Methods). (D) Ego‐dissolution is associated with psilocybin‐induced connectivity reductions between specific nodes, e.g. those crossing the two hemispheres and particularly those including medial temporal areas. Results were significant at P < 0.05 (FWE‐corrected); nodes are color‐coded according to the community structure (see Methods). Blue–Visual; Green–Somatosensory + Salience; Red–DMN + Prefrontal; Pink–Control; Dark Gray–Subcortical/MTL. [Color figure can be viewed in the online issue, which is available at http://wileyonlinelibrary.com.]