Table 3.

Main effect for ANOVA analysis (P < 0.05, FWE corrected)

Brain Region	Side	Cluster Sizes	Voxels with maximum effect
			Talairach			P‐value
			x	y	z
(A) Disease (main effect, HC<MWoA)
Cerebellum	L	3285	−18	−89	−22	0.0002
	R	2241	20	−88	−21	0.0004
Parahippocampal Gyrus	L	764	−26	−30	−15	0.0004
	R	417	18	1	−17	0.001
Hippocampus	L	63	−28	−20	−12	0.0010
	R	67	28	−20	−12	0.0012
Amygdala	L	131	−26	−7	−18	0.0004
	R	130	26	−7	−18	0.0016
Occipital cortices	L	208	−22	−88	−17	0.0010
	R	207	22	−88	−17	0.0010
(B) Disease (main effect, HC>MWoA)
Middle Frontal Gyrus	L	31	−48	16	47	0.0400
	R	369	34	35	37	0.0092
Superior Frontal Gyrus	L	81	−2	19	60	0.0100
	R	519	4	17	60	0.0110
Inferior Parietal Lobule	L	610	−53	−53	38	0.0028
	R
Precuneus	L	29	−42	−72	35	0.0102
	R	198	34	−78	41	0.0162
Supramarginal Gyrus	L	200	−59	−53	34	0.0028
	R
Inferior Temporal Gyrus	L	42	−63	−11	−18	0.0268
	R
Middle Temporal Gyrus	L	117	−53	−63	22	0.0084
	R
Superior Temporal Gyrus	L	131	−51	−57	23	0.0082
	R
Occipital cortices	L	40	−2	−82	34	0.0270
	R	55	2	−82	34	0.0300
(C) Genotype (main effect, val homozygotes>met carriers) No between‐group differences
(D) Genotype (main effect, val homozygotes<met carriers) No between‐group differences