Table 4.

Disease‐related difference in brain gray matter (P < 0.05, FWE corrected)

Brain region	Side	Cluster sizes	Voxels with maximum effect
			Talairach			P‐value
			x	y	z
(A) val homozygotes (HC<MWoA)
Cerebellum	L	3272	−20	−42	−16	0.0002
	R	2252	20	−42	−16	0.0008
Hippocampus	L	74	−24	−11	−21	0.0004
	R	69	26	−14	−18	0.0006
Amygdala	L	131	−22	−9	−18	0.0002
	R	124	28	−4	−12	0.0006
Parahippocampal Gyrus	L	714	−18	−13	−21	0.0002
	R	514	24	−18	−19	0.0008
Occipital cortices	L	128	−14	−43	−3	0.0040
	R	358	30	−90	−17	0.0050
(B) val homozygotes (HC>MWoA)
Occipital cortices	L	19	−2	−92	18	<0.0001
	R	36	2	−92	18	<0.0001
Angular Gyrus	L	63	−51	−66	31	<0.0001
(C) met carriers (HC<MWoA) No between‐group differences
(D) met carriers (HC>MWoA)
Medial frontal gyrus	L	14	−2	0	48	0.0024
	R	32	4	−3	48	0.0270
Middle frontal gyrus	L	185	−24	21	38	0.0043
	R	64	36	37	39	0.0370
Superior frontal gyrus	L	313	−22	27	45	0.0038
	R	24	4	19	62	0.0080
Precentral gyrus	L	80	−46	−13	49	0.0012
	R
Mid cingulate	L	196	−6	−4	43	0.0048
	R	17	4	−4	46	0.0276
Precuneus	L	24	−16	−44	50	0.0400
	R
Inferior parietal lobule	L	740	−46	−50	41	0.0030
	R
Postcentral gyrus	L	52	−40	−19	51	0.0106
	R
Supramarginal gyrus	L	317	−57	−55	36	0.0088
	R
Inferior temporal gyrus	L	28	−57	−7	−15	0.0079
	R	24	59	−5	−17	0.0054
Middle temporal gyrus	L	267	−53	−9	−15	0.0031
	R	293	53	−3	−12	0.0074
Superior temporal gyrus	L	291	−59	−57	25	0.0020
	R	24	48	1	−14	0.0051