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. 2019 Nov 20;10:335. doi: 10.1186/s13287-019-1410-y

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Internalization and proangiogenic effects of MSC-Exos in HUVECS. a Fluorescent microscopy showing internalization of DIO-labeled DMOG-MSC-Exos by HUVECS. Green-labeled exosomes are visible in the perinuclear region of HUVECs. b Proliferation of HUVECS treated with exosomes (50 μg/mL). c Wound healing assay of HUVECs treated with exosomes (50 μg/mL). d Quantitative analysis of wound closure. e Tube formation capacity of HUVECs treated with exosomes. f Quantitative analysis of total tube length (*P < 0.05, versus control; ^#P < 0.05, versus MSC-Exos)