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. 2014 Jul 18;35(12):5799–5814. doi: 10.1002/hbm.22586

Figure 3.

Figure 3

Brain regions showing significantly different fMRI activations with increasing N‐back task difficulty in cognitively impaired (CI) and cognitively preserved (CP) patients with multiple sclerosis (MS) vs. healthy controls (HC): (A) HC vs. CP MS patients; (B) CP MS patients vs. HC; (C) HC vs. CI MS patients; (D) CP vs. CI MS patients; (E) HC and CP MS vs. CI MS patients (conjunction analysis); (F) CP MS vs. CI MS patients and HC (conjunction analysis). Images are in neurological convention. Abbreviations: IPL, inferior parietal lobule; SPL, superior parietal lobule; PcG, precentral gyrus; IFG, inferior frontal gyrus; MFG, middle frontal gyrus; DL‐PFC, dorsolateral prefrontal cortex; SMA, supplementary motor area; ACC, anterior cingulate cortex.