Table 4.

Brain regions significantly activated/deactivated during the N‐back load condition in cognitively preserved (CP) and cognitively impaired (CI) patients with multiple sclerosis (MS) (one‐sample t test, P < 0.05 family‐wise error corrected for multiple comparisons)

Group	Contrast	Brain region	Side	BA	MNI space coordinates	Cluster extent k	T values
CP MS patients	N‐back load activations	IPL	L	40	−40 −44 46	2,631	9.6
		SPL	L	7	−28 −70 38		7.3
		IPL	R	40	38 −46 42	3,474	8.6
		SPL	R	7	20 −62 50		6.4
		Precentral gyrus	L	6	−44 4 42	11,266	7.3
		IFG	L	45	−52 28 32		10.6
		SFG	L	8	−20 16 60		6.5
		Precentral gyrus	R	44	42 6 34		7.0
		IFG	R	45	46 38 30		8.8
		MFG	R	6/8	32 14 60		7.6
		DL‐PFC	R	9	40 22 50		6.8
		SMA	L	6	−2 14 58		8.1
		ACC	R	32	8 34 40		6.1
		Insula	R	47	32 22 −6		8.7
		Insula	L	47	−36 22 −4	445	7.7
CP MS patients	N‐back load deactivations	Precuneus/PCC	L	23	−4 −46 32	6,742	9.1
		Precuneus/PCC	R	23	−2 −58 26		7.7
		STG	L	48	−44 −22 6	3,933	8.8
		STG	R	48	62 −30 22	3,019	6.5
		Mid SFG	L	10	−12 54 44	2,890	6.7
		Mid SFG	R	10	4 58 14		6.8
		Fusiform gyrus	R	37	40 −36 −24	425	6.4
CI MS patients	N‐back load activations	IPL	L	40	−44 −50 54	1,638	5.7
		SPL	L	7	−20 −72 54		5.0
		IPL	R	40	36 −56 58	287	4.0
		SPL	R	7	20 −70 52		4.6
		Precentral gyrus	L	6	−48 6 38	1,350	5.8
		IFG	L	48	−46 18 26		5.8
		SMA	R	8	2 20 48	292	5.1
		ACC	L	24	−6 2 52		4.0
CI MS patients	N‐back load deactivations	Precuneus/PCC	L	23	−6 −48 26	483	5.1
		Precuneus/PCC	R	23	8 −46 26		4.2
		STG	L	42	−58 −28 14	343	5.4
		STG	R	48	64 −20 16	261	6.3

L, left, R, right; BA, Brodmann area; IPL, inferior parietal lobule; SPL, superior parietal lobule; DL‐PFC, dorsolateral prefrontal cortex; IFG, inferior frontal gyrus; MFG, middle frontal gyrus; SMA, supplementary motor area; ACC, anterior cingulate cortex; (Mid) SFG, (medial) superior frontal gyrus; PCC, posterior cingulate cortex; STG, superior temporal gyrus.