Figure 1.

fMRI paradigm. (A) One anatomical (T1) and four functional conditions were performed on each participant. (B) During the NO‐PREFILL conditions, eight blocks of repetitive warm or cold intravesical saline infusion, rating of sensations, and passive drainage were performed. (C) Prior to the LOW‐ and HIGH‐PREFILL conditions, pre‐scan intravesical instillation of either 100 ml (for the LOW‐PREFILL) or individually adapted strong desire to void (filling until strong desire to void (SDV) is achieved for HIGH‐PREFILL) were completed. During the LOW‐ and HIGH‐PREFILL conditions eight blocks of repetitive warm saline infusion and active drainage interleaved with rating of sensations were performed. *SDV: Strong desire to void. [Color figure can be viewed in the online issue, which is available at http://wileyonlinelibrary.com.]