Table 3.

Regression coefficients of brain structures association with plasma tau

Model	B [95% CI]	β	P	R2
Model I Hippocampal volume	−0.009 [−0.012∼−0.006]	−0.628	.000	.394
Model II Hippocampal volume Education	−0.007 [−0.01∼−0.005] −1.806 [−2.626∼−0.985]	−0.519 −0.407	.000 .000	.548
Model III Hippocampal volume Education Superior frontal VBM	−0.006 [−0.009∼−0.003] −1.727 [−2.516∼−0.939] −119.908 [−216.632∼−23.183]	−0.424 −0.389 −0.235	.000 .000 .016	.593

VBM: voxel‐based morphometry; CI: confidence interval; excluded variables in Model III (ExV‐Model III): age, gender, total gray matter volume, total amygdale volume, middle and inferior frontal gyrus, superior and middle temporal gyrus, supramarginal gyrus and precuneus. In Model I, all the ExV‐Model III and hippocampal volume were entered into stepwise regression analysis; in Model II, all the ExV‐Model III, hippocampal volume and education were entered; in Model III, all the EV‐Model III, hippocampal volume, education and superior frontal VBM were entered.