Figure 1.

The thalamo‐cortical loop. Depicted is our hypothesis: a loop consisting of the thalamus connected to the cortex through thalamo‐cortical connections is affected. This is potentially caused by thalamic atrophy, disruption of cortical functional networks and changes in BOLD thalamo‐cortical functional connectivity. We further hypothesize that these alterations are interrelated and important for explaining clinical and cognitive dysfunction. [Color figure can be viewed in the online issue, which is available at http://wileyonlinelibrary.com.]