Table 3.
Correlations between functional network measures and BOLD thalamo‐cortical functional connectivity, thalamic atrophy, and clinical cognitive measures
| Thalamic volume | BOLD thalamo‐cortical functional connectivity | Average Cognition | EDSS | |
|---|---|---|---|---|
| Normalized clustering Delta | 0.16 (0.15) | −0.18 (0.10) | 0.09 (0.40) | −0.40 (<0.001) |
| Normalized clustering Theta | 0.23 (0.03) | −0.42 (<0.001) | 0.13 (0.23) | −0.17 (0.12) |
| Normalized clustering Alpha1 | 0.32 (0.003) | −0.17 (0.13) | 0.15 (0.19) | −0.31 (0.004) |
| Normalized clustering Alpha2 | 0.42 (<0.001) | −0.09 (0.42) | 0.16 (0.14) | −0.27 (0.01) |
| Normalized clustering Gamma | 0.36 (0.001) | −0.22 (0.05) | 0.12 (0.28) | −0.19 (0.08) |
| Normalized path length Theta | 0.36 (0.001) | −0.23 (0.04) | 0.26 (0.02) | −0.09 (0.40) |
| MST Leaf fraction Delta | 0.09 (0.41) | −0.24 (0.03) | 0.12 (0.30) | −0.40 (<0.001) |
| MST Leaf fraction Theta | 0.33 (0.002) | −0.31 (0.005) | 0.22 (0.05) | −0.30 (0.001) |
| MST Leaf fraction Alpha2 | 0.28 (0.01) | −0.26 (0.02) | 0.06 (0.56) | −0.17 (0.13) |
| MST Diameter Theta | −0.14 (0.21) | 0.19 (0.1) | −0.08 (0.46) | 0.05 (0.65) |
| MST Degree divergence Delta | 0.05 (0.67) | −0.14 (0.23) | 0.07 (0.54) | −0.36 (0.001) |
| MST Degree divergence Theta | 0.29 (0.007) | −0.35 (0.001) | 0.16 (0.14) | −0.28 (0.01) |
| MST Degree divergence Alpha1 | 0.23 (0.04) | −0.23 (0.04) | 0.29 (0.007) | −0.35 (0.001) |
| MST Degree divergence Alpha2 | 0.34 (0.002) | −0.22 (0.05) | 0.16 (0.15) | −0.13 (0.23) |
Values are reported as Spearman correlation values (P‐value) (step 2 of the analysis).
Bold, significant after correcting for multiple comparisons by the FDR. Italic, the result is not significant anymore after correction for multiple comparisons using the FDR (corrected for 4 × 14 tests) with FDR = p FDR *i/N. Here, p FDR = 0.05 (usual significance value in most statistical tests), i refers to the ranked index of the P‐values that are computed and N to the number of tests.