Figure 2.

The antidepressant action of ginsenoside Rg1. 5‐HT, 5‐hydroxytryptamine; Akt, protein kinase B; ASC, apoptosis‐associated speck‐like protein containing CARD; BDNF, brain‐derived neurotrophic factor; CaM, calmodulin; CaMK, CaM kinases; cAMP, cyclic adenosine monophosphate; caspase‐1, cysteinyl aspartate specific proteinase‐1; CRE, cAMP response element; CREB, cAMP response element‐binding protein; ERK, extracellular signal‐regulated kinase; GPCR, guanosine‐binding protein‐coupled receptor; IL, interleukin; MEK, MAP/ERK kinase; mTOR, mechanistic target of rapamycin; NA, noradrenaline; NLRP1, Nod‐like receptor pyrin domain‐containing protein 1; NMDAR, N‐methyl‐D‐aspartate receptor; NOX, NADPH oxidase; PI3K, phosphatidylinositol 3‐kinase; PKA, protein kinase A; PPARγ, peroxisome proliferator‐activated receptor γ; ROS, reactive oxygen species; RSK, ribosomal S‐6 kinase; TrkB, tropomyosin‐related kinase B; VDCC, voltage‐dependent calcium channel