Table 2.
MRI characteristics for controls and MCI patients with and without cerebral small vessel disease
| Controls (n = 23) | Total MCI group (n = 51) | MCI without CSVD (n = 31) | MCI with CSVD (n = 20) | |
|---|---|---|---|---|
| WMH, Fazekas scorea | 1 (0; 1) | 1 (1; 2)b | 1 (0; 1) | 2 (2; 2)b, c |
| Lacunar infarcts, presence (%) | 2 (7.7) | 12 (23.5) | 3 (9.7) | 9 (45.0)b, c |
| TIV in ml | 1,085.6 (88.4) | 1,123.7 (134.3) | 1,131.7 (122.2) | 1,111.3 (153.7) |
| Grey matter (ml) | 445.9 (56.9) | 453.8 (69.2) | 462.7 (60.8) | 439.9 (80.5) |
| White matter (ml) | 415.9 (38.2) | 402.8 (51.4)b | 412.3 (49.2) | 387.9 (52.4)b |
| WMH (ml)a | 13.1 (10.6; 21.4) | 19.9 (14.1; 30.7)b | 16.0 (10.5; 19.9) | 33.8 (25.7; 50.4)b, c |
| Left hippocampus (ml) | 3.13 (0.40) | 2.78 (0.53)b | 2.76 (0.51)b | 2.80 (0.57) |
| Right hippocampus (ml) | 3.05 (0.41) | 2.80 (0.42)b | 2.80 (0.43)b | 2.81 (0.42)b |
| FA NAWM whole brain | 0.39 (0.02) | 0.38 (0.02) | 0.38 (0.02) | 0.37 (0.02)b, c |
| MD NAWM whole brain | 0.95 (0.03) | 0.99 (0.10) | 0.99 (0.12) | 0.99 (0.08) |
| λ ІІ NAWM whole brain | 1.37 (0.03) | 1.41 (0.16) | 1.42 (0.19) | 1.38 (0.09) |
| λ ⊥ NAWM whole brain | 0.74 (0.04) | 0.79 (0.08) | 0.78 (0.09) | 0.79 (0.07) |
Values are unadjusted means (standard deviation); or number of participants (percentages).
MCI: mild cognitive impairment. CSVD: cerebral small vessel disease. TIV: total intracranial volume. WMH: white matter hyperintensities. NAWM: normal appearing white matter. MD, λ ІІ, λ ⊥ measures in 10−3.
a
Median (interquartile range).
b
Differences between groups analyzed by means of ANCOVA corrected for age and sex, Mann‐Whitney U test or χ 2 tests: p < 0.05 compared with controls.
c
Differences between groups analyzed by means of ANCOVA corrected for age and sex, Mann‐Whitney U test or χ 2 tests: p < 0.05 compared with MCI patients without CSVD.