Figure 4.

Across‐voxel correlation between ALFF and FCD. Coupling between ALFF and FCD was calculated using across‐voxel correlation in individual. Coupling calculated within the whole brain (A) and the precentral cortex (B). There was no group difference of coupling strengths within the whole brain and precentral cortex. Group differences of coupling strengths within the mesial temporal structures. (C) and default‐mode regions. (D) Moreover, ALFF‐FCD coupling strengths within the mesial temporal structures were negatively correlated with numbers of IEDs in both patient groups (left‐sided mTLE: Pearson correction: r = −0.39, P < 0.05;no correlation in Shepherd pi correlation analysis: pi = −0.33, P = 0.24. right‐sided mTLE: Pearson correction: r = −0.49, P < 0.05 Shepherd pi correlation: pi = −0.68, P < 0.01); and ALFF‐FCD coupling strengths within the default mode regions were positively correlated with epilepsy durations in the right mTLE patients (Pearson correction: r = 0.52, P < 0.01; Shepherd pi correlation: pi = 0.46, P < 0.05). [Color figure can be viewed in the online issue, which is available at http://wileyonlinelibrary.com.]