Across age groups, activation in the left caudate nucleus was observed during LTM updating (x, y, z = −10, 10, 16) for noncarriers of the DRD2/ANKK1‐Taq1a polymorphism, but not for carriers. Activation was considered significant at P < 0.001 uncorrected. [Color figure can be viewed in the online issue, which is available at http://wileyonlinelibrary.com.]