Table 2.
Activation amplitude in working‐memory network: 1‐back versus 0‐back and 2‐back versus 0‐back per region in heavy cannabis users and controls
| Brain region | MNI coordinates | Z max | 1‐Bach vs. 0‐back | 2‐Back vs. 0‐back | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| x | y | z | Cannabis users | controls | P | Cannabis users | Controls | P | ||
| Frontal pole, L | −38 | 54 | 4 | 5.25 | 0.24 (0.05) | 0.14 (0.04) | 0.12 | 0.44 (0.05) | 0.36 (0.05) | 0.26 |
| Frontal pole, R | 34 | 54 | 4 | 4.00 | 0.19 (0.05) | 0.14 (0.04) | 0.41 | 0.36 (0.04) | 0.33 (0.05) | 0.65 |
| Ventrolateral prefrontal, L | −30 | 26 | −8 | 5.27 | 0.23 (0.05) | 0.13 (0.03) | 0.05 | 0.42 (0.05) | 0.38 (0.04) | 0.57 |
| Ventrolateral prefrontal, R | 34 | 26 | −4 | 3.86 | 0.26 (0.05) | 0.11 (0.04) | 0.02 | 0.51 (0.06) | 0.37 (0.05) | 0.09 |
| Dorsolateral prefrontal, L | −46 | 10 | 32 | 6.81 | 0.21 (0.03) | 0.16 (0.03) | 0.23 | 0.42 (0.05) | 0.46 (0.05) | 0.55 |
| Dorsolateral prefrontal, R | 50 | 18 | 28 | 4.73 | 0.24 (0.04) | 0.18 (0.03) | 0.24 | 0.42 (0.05) | 0.46 (0.04) | 0.52 |
| Premotor, L | 30 | 10 | 52 | 5.33 | 0.25 (0.05) | 0.20 (0.03) | 0.41 | 0.44 (0.06) | 0.48 (0.05) | 0.56 |
| Premotor, R | −26 | 2 | 56 | 5.72 | 0.20 (0.03) | 0.19 (0.02) | 0.88 | 0.39 (0.04) | 0.40 (0.03) | 0.78 |
| Paracingulate, LR | −4 | 18 | 44 | 6.08 | 0.18 (0.05) | 0.16 (0.04) | 0.75 | 0.41 (0.06) | 0.50 (0.05) | 0.26 |
| Inferior parietal, L | −34 | −54 | 42 | 6.40 | 0.25 (0.04) | 0.21 (0.03) | 0.42 | 0.47 (0.05) | 0.53 (0.05) | 0.36 |
| Inferior parietal, R | 38 | −54 | 44 | 5.16 | 0.24 (0.03) | 0.19 (0.03) | 0.32 | 0.42 (0.04) | 0.42 (0.04) | 0.96 |
L, left hemisphere; R, right hemisphere; MNI, Montreal Neurological Institute; MNI coordinates of maximum Z‐scores are shown for each region; Values represent average percent signal change over all significant voxels within a region.