Table 2.

Anatomical regions with significant gray matter volume reductions in patients with Parkinson's disease compared with the healthy control group

MNI coordinates			Cluster size	Side	Anatomical region	Brodmann area	Z‐score
x	y	z
−12	−45	−53	8657	Lt.	Cerebellar tonsil	a	5.42
33	−70	−33		Rt.	Cerebellar tonsil	a	5.11
8	18	−3	3331	Rt.	Caudate	a	5.15
−2	8	−11		Lt.	Anterior cingulate	BA 25	4.70
−6	17	−2		Lt.	Caudate	a	4.67
−35	−12	−39	3303	Lt.	Parahippocampal gyrus	a	4.54
51	−9	4	2777	Rt.	Precentral gyrus	BA 6	5.07
56	−15	9		Rt.	Transverse temporal gyrus	BA 41	4.94
−3	−34	33	792	Lt.	Cingulate gyrus	BA 31	4.89
−48	−24	12	691	Lt.	Transverse temporal gyrus	BA 41	4.77
59	−40	4	552	Rt.	Middle temporal gyrus	BA 22	4.33
−18	−70	12	519	Lt.	Posterior cingulate	BA 30	5.13
29	−3	−21	456	Rt.	Parahippocampal gyrus	a	4.23
41	45	24	423	Rt.	Middle frontal gyrus	BA 10	4.32
15	−72	7	339	Rt.	Lingual gyrus	BA 18	4.25
33	−27	−26	328	Rt.	Parahippocampal gyrus	BA 35	4.11
56	−3	−26	264	Rt.	Middle temporal gyrus	BA 21	3.83
−8	−18	18	192	Lt.	Thalamus	a	3.76
24	62	1	166	Rt.	Superior frontal gyrus	BA 10	4.11
47	−33	62	164	Rt.	Inferior parietal lobule	BA 40	3.73
−45	−34	40	125	Lt.	Inferior parietal lobule	BA 40	4.28
−51	−13	−41	122	Lt.	Inferior temporal gyrus	BA 20	3.71
41	−76	13	121	Rt.	Middle occipital gyrus	BA 19	3.64

Gray matter volume reduction in patients with Parkinson disease is described in terms of MNI coordinates, brain regions/side, and corresponding Brodmann area. The statistical criteria for voxel‐based morphometry analysis were set as FWE corrected P _alpha < 0.05 (corrected for multiple comparisons by means of a Monte Carlo simulation). Cluster extent and Z‐score of the voxel with the strongest group effect in a given cluster are also listed. Abbreviations: BA, Broadmann area; FWE, family wised error; Lt, left side; MNI, Montreal Neurological Institute; Rt, right side.

^aIndicates that there is no Brodmann area around the center of a 5‐mm radius search range.