Table 4.

Resting‐state associated regional homogeneity (ReHo)

Brain region	Cluster size (voxels)	Cluster P‐value (FWE corrected)	MNI coordinats (x, y, z)	Hemisphere	Z‐value at voxel level
Heroin > Placebo Treatment
Posterior Cingulate Gyrus	639	<0.001	2, −28 30	R	5.84
Posterior Cingulate Gyrus			−4, −44 12	L	3.30
Thalamus	1,286	<0.001	−10, −14 12	L	5.38
Thalamus			6, −8 4	R	5.33
Thalamus			−18, −34 12	L	4.83
Postcentral Gyrus	831	<0.001	2, −38 62	R	4.66
Precentral Gyrus			0, −28 60	R	4.63
Precentral Gyrus			2, −20 70	R	4.50
Heroin < Placebo Treatment
Temporal Pole	414	0.006	−50, 2 −34	L	4.76
Inferior Temporal Gyrus			−56, −16 −26	L	4.17
Middle Temporal Gyrus			−58, −2 −26	L	4.01
Superior Frontal Gyrus	381	0.009	14, 32 62	R	4.62
Middle Frontal Gyrus			38, 22 58	R	4.29
Middle Frontal Gyrus			28, 34 52	R	4.06
Lateral Occipital Cortex	401	0.007	−36, −90 22	L	4.25
Lateral Occipital Cortex			−36, −80 42	L	4.22
Lateral Occipital Cortex			−48, −78 24	L	4.04
Controls > Heroin Treatment
Frontal Pole	259	0.039	20, 56 30	R	6.12
Superior Frontal Gyrus			10, 52 24	R	5.41
Frontal Pole			6, 58 28	R	4.75
Middle Frontal Gyrus	299	0.021	−36, 22 56	L	4.53
Middle Frontal Gyrus			−44, 20 48	L	4.29
Superior Frontal Gyrus			−18, 30 52	L	4.19
Controls < Heroin Treatment
None
Controls > Placebo Treatment
None
Controls < Placebo Treatment
None

Abbreviations: FWE: family−wise error; L: left; R: right.