Table I.
Clinical characteristics of OCD sample
| Age at onset of OCD, yr, mean ± SD (range) | 17.90 ± 6.10 (6–40) | ||
| Duration of illness, yr, mean ± SD (range) | 12.42 ± 9.93 (1–51) | ||
| Global Y‐BOCS score, mean ± SD (range) | 27.46 ± 6.55 (7–38) | ||
| Y‐BOCS obsessions score, mean ± SD (range) | 14.09 ± 3.00 (6–19) | ||
| Y‐BOCS compulsions score, mean ± SD (range) | 13.34 ± 4.26 (0–19) | ||
| OCD symptoms (Mataix‐Cols et al.'s dimensions [1999])a | 0 (absent) | 1 (mild) | 2 (prominent) |
| Symmetry and ordering, N (%) | 72 (71.29) | 11 (10.89) | 18 (17.82) |
| Hoarding, N (%) | 70 (69.31) | 22 (21.78) | 9 (8.91) |
| Contamination and cleaning, N (%) | 56 (55.44) | 20 (19.80) | 25 (24.75) |
| Aggressive and checking, N (%) | 29 (28.71) | 26 (25.74) | 46 (45.54) |
| Sexual and religious obsessions, N (%) | 79 (78.21) | 7 (6.93) | 15 (14.85) |
| Comorbid diagnoses | |||
| Significant history of depression, N (%) | 35 (34.65) | ||
| HAM‐D score at inclusion, mean ± SD (range) | 14.14 ± 5.73 (4–29) | ||
| Significant history of anxiety, N (%) | 26 (25.74) | ||
| HAM‐A score at inclusion, mean ± SD (range) | 15.19 ± 6.97 (0–33) | ||
| Treatment status | |||
| Never treated, N (%) | 6 (5.94) | ||
| One previous SRIs trial completed, N (%) | 25 (24.75) | ||
| Two previous SRIs trials completed, N (%) | 29 (28.71) | ||
| Three or more previous SRIs trials completed, N (%) | 41 (40.59) | ||
| Cumulative SRIs, mo, mean ± SD (range, median) | 35.00 ± 54.65 (0–396, 18.0) | ||
| Stable medication at time of the MRI | |||
| Medication‐free (>4 wk) | 22 (21.78) | ||
| Clomipramine hydrochloride | 33 (32.67) | ||
| Fluoxetine or Fluvoxamine maleate | 20 (19.80) | ||
| Phenelzine sulfate | 3 (2.97) | ||
| Clomipramine with fluoxetine | 23 (22.77) | ||
a
A score of 2 (prominent) was allowed for more than one dimension.
Y‐BOCS, Yale‐Brown Obsessive Compulsive Scale; HAM‐D, Hamilton Rating Scale for Depression; HAM‐A, Hamilton Rating Scale for Anxiety; SRIs, serotonin reuptake inhibitors.