Table II.
Group demographics, ADC and FA values, and number of seed voxels per region of interest for the early HD patients and their controls
| Control group B n: 14, male: 7 | Early HD n: 16, male: 12 | |||||
|---|---|---|---|---|---|---|
| Mean | SD | Range | Mean | SD | Range | |
| Age (yrs) | 51.4 | 7.9 | 42–65 | 48.2 | 10 | 31–63 |
| CAG | – | – | – | 43 | 1.6 | 41–46 |
| IQ | 102.6 | 6.6 | 88–115 | 99.6 | 12 | 72–118 |
| TFC | 12.9 | 0.3 | 12–13 | 10.6 § | 2 | 7–13 |
| UHDRS | 3.1 | 2.8 | 0–7 | 18.3 § | 10.4 | 6–45 |
| mean ± SD | mean ± SD | p | |||
|---|---|---|---|---|---|
| ADC ROI | |||||
| Corpus Callosum | 1934 ± 312 | 0.80 ± 0.031 | 1445 ± 371 *** | 0.85 ± 0.040 * | 0.000 |
| Caudate Nucleus | 57 ± 12 | 0.74 ± 0.048 | 40 ± 7 *** | 0.83 ± 0.069 * | 0.001 |
| Thalamus | 2480 ± 531 | 0.74 ± 0.032 | 3102 ± 1062 | 0.74 ± 0.034 | 0.863 |
| FA ROI | |||||
| Corpus Callosum | 1934 ± 312 | 0.75 ± 0.012 | 1445 ± 371 *** | 0.73 ± 0.033 | 0.046 |
| Caudate Nucleus | 57 ± 12 | 0.17 ± 0.018 | 40 ± 7 *** | 0.19 ± 0.019 | 0.072 |
| Thalamus | 2480 ± 531 | 0.33 ± 0.021 | 3102 ± 1062 | 0.32 ± 0.034 | 0.950 |
| # voxels ± SD | mean ± SD | # voxels ± SD | mean ± SD | ||
| ADC Fiber pathway | |||||
| Corpus Callosum | 1934 ± 312 | 0.89 ± 0.051 | 1445 ± 371 *** | 0.95 ± 0.067 ** | 0.008 |
| Caudate Nucleus | 57 ± 12 | 0.88 ± 0.107 | 40 ± 7 *** | 0.97 ± 0.079 | 0.023 |
| Thalamus | 2480 ± 531 | 0.85 ± 0.080 | 3102 ± 1062 | 0.93 ± 0.063 ** | 0.007 |
| Motor cortex | 589 ± 117 | 0.79 ± 0.023 | 593 ± 110 | 0.82 ± 0.027 ** | 0.001 |
| Prefrontal cortex | 1118 ± 239 | 0.88 ± 0.023 | 1202 ± 274 | 0.95 ± 0.056 ** | 0.000 |
| FA Fiber pathway | |||||
| Corpus Callosum | 1934 ± 312 | 0.48 ± 0.013 | 1445 ± 371 *** | 0.47 ± 0.017 | 0.027 |
| Caudate Nucleus | 57 ± 12 | 0.35 ± 0.027 | 40 ± 7 *** | 0.35 ± 0.021 | 0.592 |
| Thalamus | 2480 ± 531 | 0.41 ± 0.016 | 3102 ± 1062 | 0.41 ± 0.024 | 0.644 |
| Motor cortex | 589 ± 117 | 0.38 ± 0.019 | 593 ± 110 | 0.37 ± 0.024 | 0.059 |
| Prefrontal cortex | 1118 ± 239 | 0.39 ± 0.016 | 1202 ± 274 | 0.38 ± 0.014 ** | 0.006 |
SD, standard deviation; CAG, CAG repeat length; IQ, estimate of premorbid intelligence quotient; TFC, total functional capacity score.
UHDRS, Unified Huntington's disease rating scale total motor score.
Significant difference from control group, P < 0.01. ROI, region of interest analysis; ADC, apparent diffusion coefficient in μm2/ms; FA, fractional anisotropy (no unit); Fiber pathway, fiber pathways analysis between the listed region and the rest of the brain.
P <0.017,
P < 0.01 (adjusted for multiple comparisons). # voxels: mean number of voxels in the listed seed region.
Number of voxels differs significantly from healthy controls.