Table III.

Standardized correlation coefficients matrix for ADC of white matter fiber bundles and clinical measures in all participants

	Motor		Cognitive				Behavior
	Tapping	Tongue	SDMT	SWR	TMT B	SPOT	BDI‐II	FrSBe Disinhib	FrSBe Exec dysf	FrSBe apathy
Corpus Callosum	0.38 **	0.27	−0.32 *	−0.39 **	0.36 **	−0.39 **	0.11	0.01	0.09	0.10
Caudate Nucleus	0.13	0.23	−0.08	−0.04	0.13	−0.19	−0.05	0.05	−0.02	−0.01
Thalamus	0.41 **	0.33 *	−0.27	−0.28	0.26	−0.30	0.02	0.03	0.09	0.07
Motor cortex	0.46 **	0.32 *	−0.46 **	−0.52 **	0.55 **	−0.33 *	0.15	−0.02	0.11	0.17
Prefrontal cortex	0.33 *	0.28	−0.28	−0.34 *	0.25	−0.28	0.15	−0.02	−0.06	0.04

	Genetics	Probability of onset	Burden of Pathology	Oculomotor
	CAG Gene carriers only	Within 5 years (preHD only)	(CAG‐35.5) × age	Latency of antisaccades	Error % of antiscaccades
Corpus Callosum	0.36	0.61 **	0.51 **	−0.32 *	−0.39 **
Caudate Nucleus	0.09	0.42	0.27	−0.08	−0.04
Thalamus	0.10	0.06	0.19	−0.27	−0.28
Motor cortex	0.32	0.58 **	0.52 **	−0.46 **	−0.52 **
Prefrontal cortex	0.09	0.41 *	0.37	−0.28	−0.34 *

Tapping, Average speeded tapping intertap variability for left and right index finger; Tongue, sustained tongue force measure; SDMT, Symbol Digit Modalities test; SWR, Stroop word reading task; TMT B, Trail making test part B; SPOT, Visual array comparison task for visual short‐term memory capacity; BDI‐II, Becks Depression Inventory 2nd version; FrSBe = Frontal Systems Behaviour rating scale Self Report; disinhibtion, executive dysfunction and apathy subscores; CAG, CAG repeat length (in gene carriers only); Expected years to onset correlation is only for premanifest gene carriers. All correlations are controlled for the effects of age and gender.

^* P < 0.01,

^** P < 0.005