Table I.
Demographic data, MMSE, and CDR scores, whole brain as well as frontal and temporal gray matter volumes (TIV‐corrected) of controls and patients at baseline, and atrophy progression rates
| CON | bvFTLD | PNFA | SemD | |
|---|---|---|---|---|
| Age (years) | 62.9 (7.7) | 64.2 (9.2) | 69.2 (7.6) | 63.8 (9.8) |
| Disease duration (years) | N/A | 2.0 (1.5) | 4.0 (4.0) | 3.0 (1.0) |
| Sex (F/M) | 17/13 | 4/2 | 1/3 | 3/4 |
| MMSE score (/30) | 29.1 (1.1)a | 23.3 (4.2) | 24.3 (5.6) | 25.7 (2.1) |
| CDR score (median) | N/A | 0.75 | 0.5 | 0.5 |
| CDR sum of boxes (median) | N/A | 3.75 | 2.25 | 2.0 |
| Absolute volumes at baseline (TIV‐corrected) | ||||
| Brain (ml) | 1126.0 (67.0) | 917.2 (69.7)b | 1031.1 (73.2)c | 1048.7 (132.3) |
| Left TL (ml) | 64.5 (5.7) | 52.0 (7.0)b | 54.6 (9.4)b | 47.9 (6.8)b |
| Right TL (ml) | 65.0 (5.3) | 53.3 (4.3)b | 58.0 (3.3)c | 56.5 (8.8)b |
| Left FL (ml) | 84.4 (7.9) | 61.8 (13.6)b | 70.1 (6.9)b | 76.3 (13.9) |
| Right FL (ml) | 87.3 (8.1) | 64.4 (10.6)b | 74.6 (8.0)b | 81.2 (15.0) |
| Atrophy progression rates (per 6 months) | ||||
| Brain (%) | N/A | 1.41 (1.13) | 1.94 (0.74) | 2.04 (1.52) |
| Left TL (%) | N/A | 1.56 (2.06) | 2.75 (1.25) | 4.41 (2.07) |
| Right TL (%) | N/A | 1.35 (1.44) | 2.46 (1.52) | 3.38 (3.24) |
| Left FL (%) | N/A | 2.64 (1.64) | 3.06 (1.15) | 2.74 (2.25) |
| Right FL (%) | N/A | 2.38 (1.56) | 3.42 (3.65) | 2.54 (2.27) |
Arithmetic mean (SD), except as indicated.
a
MMSE scores were determined in 15/30 healthy control participants.
b
Significance at P < 0.01.
c
Significant difference between diagnostic group and CON (P < 0.05; two‐sample T‐test).
CON, controls; bvFTLD, behavioral variant FTLD; PNFA, progressive nonfluent aphasia; SemD, semantic dementia; TIV, total intracranial volume; TL, temporal lobe; FL, frontal lobe.