Table I.
A summary of published normative putamen right, left volume in milliliters and computed asymmetry index of the putamen volume using several manual and automated methods along with the control population demographics
| Author and year | N(H/S) controls | Age (years) | Delineation methods | Right PUT Vol (mL) | Left PUT Vol (mL) | AI | Age r(p) |
|---|---|---|---|---|---|---|---|
| Ahsan et al., 2007 | 30 (15M; 25Rh) | 31 (median) 20–54 | Rater no. 1 | 4.54 ± 0.63 | 4.61 ± 0.63 | −1.5 | |
| Rater no. 2 | 4.34 ± 0.61 | 4.26 ± 0.50 | 1.9 | ||||
| Automatic | 6.72 ± 0.64 | 7.03 ± 0.70 | −4.5 | ||||
| Anastasi et al., 2006 | 35 Rh (21M) | 34 (mean) 22–43 | Automatic (NURBS) | 3.43 ± 0.14 | 3.37 ± 0.19 | 3.4 | |
| Brambilla et al., 2001 | 22 (14M) | 38 ± 10 | Manual | 2.43 ± 0.93 | 3.18 ± 0.92 | −26.7 | −0.33 (0.14) |
| de Jong et al., 2008 | 35 (M) | 65 ± 13 | FSL‐FIRST (SIENAX) | 6.47 ± 0.86 | 5.90 ± 0.77 | 12.3 | |
| 35 (F) | 67 ± 12 | 5.56 ± 0.75 | 5.24 ± 0.61 | 5.9 | |||
| Greenberg et al., 2006 | 138 (38M) | 71 ± 6 | Automatic GRID | 3.58 ± 0.67 | 3.56 ± 0.62 | 0.6 | −0.22 |
| 60–85 | 0.32 ± 0.06 | 0.32 ± 0.06 | −0.37 | ||||
| Gunning‐Dixon et al., 1998 | 148 (Rh) | 46.5 ± 17.2 | Manual | 4.36 ± 0.61 | 4.02 ± 0.60 | 8.1 | −0.41 |
| 82 (W) | 47.4 ± 18.1(W) | 4.19 ± 0.53(W) | 3.88 ± 0.54 (W) | 7.7 | −0.43 | ||
| 66 (M) | 45.7 ± 16.5(M) | 4.56 ± 0.64(M) | 4.18 ± 0.62 (M) | 8.7 | −0.43 | ||
| 18–77 | |||||||
| Jacobsen et al., 2001 | 20 (9M) | 35.0 ± 6.8 | ANALYZE | 4.0 | 3.7 | 9.0 | −0.40 |
| 22–48 | 0.291 ± 0.034 | 0.266 ± 0.030 | |||||
| Jovicich et al., 2009 | 15 | 69.5 ± 4.8 | FreeSurfer | 4.35 ± 0.70 | 4.65 ± 0.85 | −6.6 | |
| 4 | 34 ± 3 | 5.64 ± 0.89 | 5.88 ± 0.83 | −4.2 | |||
| Keshavan et al., 1998 | 17 (12M) | 22.9 ± 5.1 | Manual | 2.91 ± 0.89 | 2.37 ± 1.13 | 20.5 | |
| Mcdonald et al., 2008 | 21 (10M) | 33.0 ± 10.2 | FreeSurfer ICV‐cov | 5.07 ± 0.11 | 5.26 ± 0.11 | −3.7 | |
| Peran et al., 2009 | 30 (16M) | 29.3 ± 5.7 | FSL‐FIRST | 6.66 ± 0.61 | 6.47 ± 0.73 | 2.9 | −0.43 |
| 20–41 | −0.43 | ||||||
| Rosas et al., 2001 | 24 (12M) | 41.2 ± 9.8 | Automatic | 4.5 ± 0.7 | 4.7 ± 0.7 | −4.3 | −0.36 |
| 29–62 | |||||||
| Shattuck et al., 2008 | 40 (20F) | 29.2 ± 6.3 | Manual | 4.22 ± 0.49 | 4.25 ± 0.52 | −0.7 | |
| 19.3–39.5 | LPBA40/AIR | 5.13 ± 0.61 | 5.17 ± 0.73 | −0.8 | |||
| FLIRT | 5.83 ± 0.63 | 5.87 ± 0.69 | −0.7 | ||||
| SPM5 | 5.77 ± 0.62 | 5.69 ± 0.68 | 1.4 | ||||
| Vernaleken et al., 2007 | 18 (M) | 35.6 ± 10.4 | Manual | 4.85 ± 0.56 | 4.64 ± 0.86 | 4.4 | −0.61 |
| Rh | 24–60 | −0.43 |
The putamen volume vs. age correlation coefficient was listed whenever provided in the original papers.
Notes:
1. Papers are alphabetized by leading author last name and year. Tabulated putamen volume (PUTV) values are mean ± standard deviation. The values are taken from healthy controls.
2. Putamen volume asymmetry index, AI = 2*(RPUTV − LPUTV)/(LPUTV + LPUTV) × 100%, where RPUTV, right putamen volume in mL; LPUTV, left putamen volume in mL; Rh, right handed; M, males; F, females.
3. The age correlation (p) is the Pearson's correlation coefficient, which corresponds to the linear model: y = a + β * x, where x is age in years and y may correspond to the absolute, covaried or ICV‐normalized putamen right or left volume. Note that the slope of regression or atrophy annual rate is related to the Pearson linear correlation coefficient by the relation: β = r*s(y)/s(x).
4. Underlined values are putamen volumes to ICV percentage (e.g., covaried with ICV).
5. Tabulated putamen volume versus age correlations are all significant (P < 0.01).