Table II.
Cervical cord and brain structural MR quantities in control subjects and patients with primary progressive (PP) and secondary progressive (SP) multiple sclerosis (MS)
| Control subjects | PPMS patients | SPMS patients | P‐valuesa | |
|---|---|---|---|---|
| Normalized cord cross‐sectional area (SD) [mm2] | 82.6 (4.6) | 70.4 (7.7) | 69.6 (0.5) | <0.001 |
| Cord average MD (SD) [×10−3 mm2 s−1] | 0.84 (0.09) | 0.98 (0.07) | 0.97 (0.12) | <0.001 |
| Cord average FA (SD) | 0.57 (0.06) | 0.44 (0.05) | 0.46 (0.05) | <0.001 |
| Brain T2 LV (SD) (ml) | — | 8.8 (11.2) | 28.1 (19.3) | 0.001b |
| Brain GM average MD (SD) [×10−3 mm2 s−1] | 0.89 (0.04) | 0.94 (0.05) | 0.98 (0.04) | 0.001 |
| Brain NAWM average MD (SD) [×10−3 mm2 s−1] | 0.77 (0.02) | 0.78 (0.02) | 0.82 (0.03) | <0.001 |
| Brain NAWM average FA (SD) | 0.40 (0.02) | 0.38 (0.02) | 0.34 (0.03) | <0.001 |
| Normalized brain volume (SD) [ml] | 1567 (79) | 1527 (64) | 1430 (67) | <0.001 |
| GM volume (SD) [ml] | 828 (59) | 808 (73) | 691 (80) | <0.001 |
| WM volume (SD) [ml] | 739 (38) | 718 (28) | 729 (67) | 0.38 |
Abbreviations: MS = multiple sclerosis; SP = secondary progressive; PP = primary progressive; MD = mean diffusivity; FA = fractional anisotropy; SD = standard deviation; GM = grey matter; WM = white matter; NAWM = normal‐appearing white matter; LV = lesion volume.
a
ANOVA model adjusted for age.
b
Mann‐Withney U test.